Cellular and molecular mechanisms responsible for CNS homeostasis, Diseases and Regeneration；
Cancer Stem cells；
Epigenetics in Cancer biology；
Cancer immunotherapy

1994: B.S., Department of Biochemistry and molecular biology, Wuhan University， Wu’han, China
2001: M.S., Institute of Neurosciences, the Fourth Military Medical University，Xi’an, China
2004: M.D. &Ph.D., Institute of Neurosciences, the Fourth Military Medical University，Xi’an, China

2015.1-Present, Associate Professor, School of Electronic Information and Electronic Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China
2006.3-2014-12, Associate Investigator, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China
2004.8-2006.2, Lecturer, Institute of Neurosciences, the Fourth Military Medical University, Xi’an, China
1994.8-1998.7, Research Assistant, Institute of Neurosciences, the Fourth Military Medical University, Xi’an, China.

Dr. Wei-Lin Jin is an Associated Professor at Shanghai Jiao Tong University. His research interest mainly focuses on molecular mechanism of neural repair and the fundamental issue of cancer biology and pharmacotherapeutics.
CNS neural development and regeneration is his first interest. He is very interested in investigating the cellular and molecular mechanisms responsible for CNS homeostasis, diseases and regeneration. In his lab, they first found the adapter proteins SrGAP1-3 occurring nuclear translocation during brain development; further investigation revealed that they can interact with chromatin remodeling factor Brg1 and thus affect dendritic development. The abnormalities of these molecules are closely related to neurodevelopmental diseases, such as mental retardation, schizophrenia, autism and seizure. Another important breakthrough from his group is identified a novel domain from Nogo-A, originally cloned from myelin. They found that M9 domain in amino-Nogo-A has a neuroprotective role against oxidative stress. The reagent may be an approach or translational potentials as molecular intervention in axon regeneration, cerebral ischemia and neurodegeneration diseases.
In the cancer biology, Prof. Jin focuses on cancer stem cells and cancer epigenetics. He hopes to understand the adaption of cancer stem cells in hypoxic and high ROS environment and try to search for some new strategies for treatment.
As PI, Dr. Jin was rewarded four grants from National Natural Science Foundation of China in the last five years. He has published more than 60 peer-reviewed publications and their findings have been published in some important professional journals, such as Cell, Nature Communications, Cancer Res, Cell Death and Differentiation, Biomaterials, Pharmacology & Therapeutics, Med Res Rev, Cancer Letters, Oncotarget, Molecular and cellular Neuroscience, J Comp Neurol and Anesthesiology.

1.Qiu GZ#, Jin MZ#, Dai JX#, Sun W, Feng JH, Jin WL*. Reprogramming of the tumor in the hypoxic niche: the emerging concept and associated therapeutic strategies. Trends Pharmacol Sci. 2017 Jun 8. pii: S0165-6147(17)30110-4. doi: 10.1016/j.tips.2017.05.002. [Epub ahead of print]
2.Jin WL#*, Mao XY#, Qiu GZ#. Targeting Deubiquitinating Enzymes in Glioblastoma Multiforme: Expectations and Challenges. Med Res Rev. 2017 May; 37 (3): 627-661.
3.Chu H#, Sun P#, Yin J#, Liu G, Wang Y, Zhao P, Zhu Y, Yang X, Zheng T, Zhou X*, Jin W*, Sun C*. Integrated network analysis reveals potentially novel molecular mechanisms and therapeutic targets of refractory epilepsies. PLoS One. 2017 Apr 7; 12(4):e0174964. doi: 10.1371/journal.pone.0174964. eCollection 2017.
4.Zou YX#, Qiu GZ#, Jiang L#, Cai Z, Sun W, Hu HK, Lu CY, Jin WL*, Hu GH*. Overexpression of ubiquitin specific proteases 44 promotes the malignancy of glioma by stabilizing tumor-promoter securin. Oncotarget. 2017 Mar 22. DOI: 10.18632/oncotarget.16447 [Epub ahead of print]
5.Ma Y, Fu HL, Wang Z, Huang H, Ni J, Song J, Xia Y, Jin WL*, Cui DX*. USP22 maintains gastric cancer stem cell stemness and promotes gastric cancer progression by stabilizing BMI1 protein. Oncotarget. 2017 May 16;8(20):33329-33342. doi: 10.18632/oncotarget.16445.
6.Wang M#, Li X#, Zhang J, Yang Q, Chen W, Jin W, Huang YR*, Yang R*, Gao WQ*. AHNAK2 is a Novel Prognostic Marker and Oncogenic Protein for Clear Cell Renal Cell Carcinoma. Theranostics 2017; 7(5):1100-1113. doi:10.7150/thno.18198.
7.Qiu GZ, Sun W, Jin MZ, Lin J, Lu PG* and Jin WL*. The bad seed gardener: Deubiquitinases in the cancer stem-cell signaling network and therapeutic resistance. Pharmacol Ther. 2017 Apr;172:127-138. doi: 10.1016/j.pharmthera.2016.12.003. Review
8.Liu N#, Zhang L#, Wang Z, Cheng YD，Zhang PX，Wang X，Yang HW，Liu H，Jin WL*，Zhang YS*，Tu YY*. MicroRNA-101 Inhibited Proliferation, Migration and Invasion of Human Glioblastoma by Targeting SOX9. Oncotarget. 2017 Mar 21;8(12):19244-19254.
9.Zhao J, Ma XL*, Ma JX, Sun L, Lu B, Wang Y, Xing GS, Wang Y, Dong BC, Xu LY, Kuang MJ, Fu L, Bai HH, Ma Y, Jin WL.TET3 Mediates Alterations in the Epigenetic Marker 5hmC and Akt pathway in Steroid-Associated Osteonecrosis. J Bone Miner Res. 2017 Feb; 32(2):319-332.
10.Gao X#, Mi Y#, Guo N#, Hu Z, Hu F, Liu D, Gao L, Gou X*, Jin W*. Disrupted in schizophrenia 1 (DISC1) inhibits glioblastoma development by regulating mitochondria dynamics. Oncotarget. 2016 Dec 27;7(52):85963-85974. doi: 10.18632/oncotarget.13290
11.Jiao Q, Wang L, Zhang Z, Wang Y, Yan H, Ma W, Jin W, Lu H*, Liu Y*. Dynamic expression of srGAP2 in cell nuclei and cytoplasm during the differentiation of rat neural stem cells in vitro. Mol Med Rep.2016 Nov;14(5):4599-4605.
12.Ma Y, Fu H, Zhang C, Cheng S, Gao J, Wang Z, Jin W*, Conde J*, Cui D*. Chiral Antioxidant-based Gold Nanoclusters Reprogram DNA Epigenetic Patterns. Sci Rep. 2016 Sep 16;6:33436. doi: 10.1038/srep33436.
13.Lian H, Li WB*, Jin WL*. The emerging insights into catalytic or non-catalytic roles of TET proteins in tumors and neural development. Oncotarget. 2016 Aug 19, 7(39): 64512-64525.Review.
14.Mao XY*, Li QQ, Gao YF, Zhou HH, Liu ZQ*, Jin WL*. Gap junction as an intercellular glue: Emerging roles in cancer EMT and metastasis. Cancer Lett. 2016 Oct 10; 381 (1): 133-137.
15.Fu H*, Ma Y, Yang M, Zhang C, Huang H, Xia Y, Lu L, Jin W*, Cui D*. Persisting and Increasing Neutrophil Infiltration Associates with Gastric Carcinogenesis and E-cadherin Downregulation. Sci Rep. 2016 Jul 14;6:29762. doi: 10.1038/srep29762.
16.Yanyang Tu#, Zhen Wang#, Xin Wang, Hongwei Yang, Pengxing Zhang, Mark Johnson, Nan Liu, Hui Liu, Weilin Jin*, Yongsheng Zhang*, Daxiang Cui*.Birth of MTH1 as a therapeutic target for glioblastoma: MTH1 is indispensable for gliomatumorigenesis. Am J Transl Res 2016 Jun; 8(6):2803-2811.
17.Xu CJ*.#, Wang JL#, Jin WL*. The Emerging Therapeutic Role of NGF in Alzheimer's Disease. Neurochem Res. 2016 Jun;41(6):1211-8.
18.Gao J, Ma Y, Fu HL, Luo Q, Wang Z, Xiao YH, Yang H, Cui DX and Jin WL*. Non-catalytic roles for TET1 protein negatively regulating neuronal differentiation through srGAP3 in neuroblastoma cells. Protein Cell. 2016 May; 7(5):351-61.
19.Mao XY*, Dai JX, Zhou HH, Liu ZQ*, Jin WL*.Brain tumor modeling using the CRISPR/Cas9 system: state of the art and view to the future. Oncotarget. 2016 May 31;7(22):33461-33471. doi: 10.18632/oncotarget.8075. Review.
20.Mao XY*, Tokay T, Zhou HH, Jin WL*. Long-range and short-range tumor-stroma networks synergistically contribute to tumor-associated epilepsy. Oncotarget. 2016 May 31; 7(22):33451-33460.doi: 10.18632/oncotarget.7962. Review.
21.Lin XB#, Jiang L#, Ding MH, Chen ZH, Bao Y, Chen Y, Sun W, Zhang CR, Hu HK, Cai Z, Lu CY, Zhou JY, Qian J, Wu XJ, Jin WL*, Hu GH*. Anti-tumor activity of phenoxybenzamine hydrochloride on malignant glioma cells. Tumour Biol. 2016 Mar;37(3):2901-8.
22.Li L, Deng B, Wang S, Zhong H, Liu Z, Jin W, Jiang T, Xiao Z, Wang Q. synchronous therapy targeting Nogo-A enhances neurobehavioral recovery by reducing neuronal loss and promoting neurite outgrowth after cerebral ischemia in mice. J Drug Target. 2016; 24 (1):13-23.
23.Dai Jinxiang, Bercury Kathryn, Jin Weilin and Macklin Wendy*. Olig1 acetylation and nuclear export mediate oligodendrocyte development. The Journal of Neuroscience, December 2, 2015, 35(48):15875–15893.
24.Wang B, Ma A, Zhang L, Jin WL, Qian Y, Xu G, Qiu B, Yang Z, Liu Y, Xia Q, Liu Y. POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation.Nat Commun. 2015 Oct 29;6:8704. doi: 10.1038/ncomms9704.
25.Li C, Ruan J, Yang M, Pan F, Gao G, Qu S, Shen YL, Dang YJ, Wang K, Jin WL, Cui DX*. Human induced pluripotent stem cells labeled with fluorescent magnetic nanoparticles for targeted imaging and hyperthermia therapy for gastric cancer. Cancer Biol Med. 2015 Sep;12(3):163-74. doi: 10.7497/j.issn.2095-3941.2015.0040.
26.Mi, Y#.; Gao, X#.; Dai, J.; Ma, Y.; Xu, L*.; Jin, W*. A Novel Function of TET2 in CNS: Sustaining Neuronal Survival. Int. J. Mol. Sci. 2015, 16, 21846-21857.
27.Ding MH#, Wang Z#, Jiang L#, Fu HL, Gao J, Lin XB, Zhang CL, Liu ZY, Shi YF, Qiu GZ, Ma Y, Cui DX, Hu GH*, Jin WL*. The transducible TAT-RIZ1-PR protein exerts histone methyltransferase activity and tumor-suppressive functions in human malignant meningiomas. Biomaterials 2015 Jul; 56 (3): 165-178. doi: 10.1016/j.biomaterials.2015.03.058
28.Zhang J, Song Y, Zhang C, Zhi X, Fu H, Ma Y, Chen Y, Pan F, Wang K, Ni J, Jin W, He X*, Su H*, Cui D*. Circulating MiR-16-5p and MiR-19b-3p as Two Novel Potential Biomarkers to Indicate Progression of Gastric Cancer. Theranostics 2015; 5(7):733-745. doi:10.7150/thno.10305.
29.Xu CJ*, Wang JL, Jin WL*. The Neural Stem Cell Microenvironment: Focusing on Axon Guidance Molecules and Myelin-Associated Factors. J Mol Neurosci. 2015 Mar 11. [Epub ahead of print]
30.Zhang C, Zhou Z, Zhi X, Ma Y, Wang K, Wang Y, Zhang Y, Fu H, Jin W, Pan F, Cui D. Insights into the Distinguishing Stress-induced Cytotoxicity of Chiral Gold Nanoclusters and the Relationship with GSTP1. Theranostics 2015; 5(2):134-149. doi:10.7150/thno.10363.
31.Mi, Y. #*, Gao, X#., Ma, Y., Gao, J., Wang, Z., and Jin, W.L.* A novel centrosome and microtubules associated subcellular localization of Nogo-A: implications for neuronal development, International Journal of Biochemistry and Cell Biology. 2014 December, 57:1-6
32.Xing-Chun Gao#*, Ya-Jing Mi#, Yue Ma, Weilin Jin*. LEF1 regulates glioblastoma cell proliferation, migration, invasion, and cancer stem-like cell self-renewal. Tumour Biol. 2014 Nov. 35:11505–11511.
33.Xing-Chun Gao, Weilin Jin*. The Emerging Role of Tumor-Suppressive MicroRNA-218 in Targeting Glioblastoma Stemness. Cancer Lett. 2014 Oct 10; 353(1):25-31. doi: 10.1016/j.canlet.2014.07.011. Epub 2014 Jul 17.
34.Hua-Lin Fu, Yue Ma, Lun-Gen Lu, Peng Hou, Baojie Li, Weilin Jin*, and Da-Xiang Cui*. TET1 Exerts Its Tumor Suppressor Function by Interacting with p53-EZH2 Pathway in Gastric Cancer. J. Biomed. Nanotechnol. 2014. 10, 1217-1230.
35.Xiang-Hui Zhao#*, Jin-Xiang Dai#, Yue Ma, Ya-Jing Mi, Daxiang Cu, Gong Ju, Wendy B. Macklin, Weilin Jin*. Dynamics of Tet hydroxylase family proteins and 5-hydroxymethylcytosine in oligodendrocyte differentiation. Glia. 2014; 62(6):914-26.
36.Yun-Kai Dai#, Yue Ma #, Keng Chen #, Ya-Jing Mi, Hua-Lin Fu, Da-Xiang Cui and Weilin Jin*. A link between the nuclear-localized srGAP3 and the SWI/SNF chromatin remodeler Brg1. Mol Cell Neurosci. 2014, 60: 10-25.
37.He N, Jin WL, Lok K-H, Wang Y, M Yin* and Wang Z-J *. Amyloid-β1-42 oligomer accelerates senescence in adult hippocampal neural stem/progenitor cells via formylpeptide receptor 2. Cell Death & Disease 2013; 4:e924. doi: 10.1038/cddis.2013.437.
38.Yanyang Tu#, Xingchun Gao#, Gang Li #, Hualin Fu, Daxiang Cui, Hui Liu, Weilin Jin*, Yongsheng Zhang *. MicroRNA-218 Inhibits Glioma Invasion, Migration, Proliferation and Cancer Stem-like Cell Self-renewal by Targeting the Polycomb Group Gene Bmi1. Cancer Res. 2013; 73(19); 6046–6055.
BREAKING ADVANCES: Highlights from Recent Cancer Literature. Cancer Res., Oct 2013; 73: 6097 - 6098.
BREAKING ADVANCES: Highlights from Recent Cancer Literature. Cancer Res.,Sep 2013; 73: 5607 - 5608.
39.Qi Yang, Kexia Wu, Meiju Ji, Weilin Jin, He N, Shi B, Hou P. Decreased 5-hydroxymethylcytosine (5-hmC) is an independent poor prognostic factor in gastric cancer patients. J Biomed Nanotechnol. 2013; 9(9):1607-1616.
40.Haixia Lu, Qian Jiao, Yuanyuna Wang, Zhiqiang Yang, Mianjuan Feng, Li Wang, Xinlin Chen, Weilin Jin*, Yong Liu *. The mental retardation associated protein srGAP3 regulates survival, proliferation and differentiation of rat embryonic neural stem/progenitor cells. Stem Cells and Development. 2013, 22(11): 1709-1716.